Applications
2020 Publications on Tethered Lipid Bilayer Membranes
Improved micro-impedance spectroscopy to determine cell barrier properties
Md. Mehadi Hassan Sohag, Oliver Nicoud, Racha Amine, Abir Khalil-Mgharbel, Isabelle Vilgrain, Donald K Martin
The Eurobiotech Journal Vol 4 Issue 3 July2020 doi: 10.2478/ebtj-2020-0017
2018 Publications on Tethered Lipid Bilayer Membranes
A biomemetic lipid membrane device reveals interaction of cancer biomarkers with human serum lipidic moieties
Abir Khalil-Mgharbel, Helena Polena, Paul K. Demb_el_e, Md. Mehadi Hassan Sohag, Jean Pierre Alcaraz, , Donald K Martin, Isabelle Vilgrain
Biotechnol. J, 2018, 13, 1800463 doi: 10.1002/biot.201800463
The effect of hydronium ions on the structure of phospholipid membranes
Evelyne Deplazes, David Poger, Bruce Cornell, Charles Cranfield
Phys Chem Chem Phys Issue 1 2018 doi: 10.1039/C7CP06776C
2017 Publications on Tethered Lipid Bilayer Membranes
Pore forming peptides
Kalata B1 and Kalata B2 have a Surfactant-Like Activity in Phosphatidylethanolamine-Containing Lipid Membranes
Charles Cranfield, Sonia Troeira Henriques, Boris Martinac, Paul Duckworth, David Craig, Bruce Cornell
Langmuir, 2017, 33 (26), pp 6630–6637 doi: 10.1021/acs.langmuir.7b01642
Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents
Rajesh Kuppusamy et al. European Journal of Medicinal Chemistry 2017 in press
https://doi.org/10.1016/j.ejmech.2017.10.066
Membrane Biophysics
The effect of Cholesterol on the Dielectric Structure of Lipid Membranes
Adeel Alobeedallah, Bruce Cornell, Hans Coster
The Journal of Membrane Biology 29 November 2017 doi.org/10.1007/s00232-017-0007-6
2016 Publications on Tethered Lipid Bilayer Membranes
Pore forming peptides
Candidalysin is a fungal peptide critical for mucosal infection
David L Moyes et al
Nature 2016 532 64-68 doi:10.1038/nature17625
Membrane Biophysics
The Effect of Benzyl Alcohol on the Dielectric Structure of Bilayers
Hadeel Alobeedallah, Bruce Cornell, Hans Coster
The Journal of Membrane Biology; November 2016, doi: 10.1007/s00232-016-9934
The Effect of Tethers on Artificial Cell Membranes: A Coarse-Grained Molecular Dynamics Study.
Hoiles W, Gupta R, Cornell B, Cranfield C, Krishnamurthy V
PLoS One 2016 Oct 13;11(10):e0162790. doi: 10.1371/journal.pone.0162790. eCollection 2016
Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology
Charles G. Cranfield, Thomas Berry, Stephen A. Holt, Khondker R. Hossain, Anton P. Le Brun, Sonia Carne, Heba Al Khamici, Hans Coster, Stella M. Valenzuela, and Bruce Cornell
Langmuir, 2016, 32 (41), pp 10725–10734 doi: 10.1021/acs.langmuir.6b01988
Ion Channels
Investigating Sterol and Redox Regulation of the Ion Channel Activity of CLIC1 Using Tethered Bilayer Membranes
Heba Al Khamici 1, Khondker R. Hossain 1,2, Bruce A. Cornell 3 and Stella M. Valenzuela
Membranes 2016, 6(4), 51; doi:10.3390/membranes6040051
Elucidating the Mechanism for Sterol Regulation of Chloride Intracellular Ion Channel Protein Interactions with Lipid Membranes
Khondker R. Hossain, Heba Al Khamici, Stephen A. Holt, Stella M. Valenzuela
Biophysical Journal Volume 110, Issue 3, Supplement 1, p204a, 16 February 2016 doi; http://dx.doi.org/10.1016/j.bpj.2015.11.1139
2015 Publications
The assembly and use of tethered bilayer lipid membranes (tBLMs).
Cranfield C1, Carne S, Martinac B, Cornell B. Methods Mol Biol. 2015;1232:45-53. doi: 10.1007/978-1-4939-1752-5_4.
Nanoscale Ion Sequestration To Determine the Polarity Selectivity of Ion Conductance in Carriers and Channels
Charles G. Cranfield, Taren Bettler, and Bruce Cornell
Langmuir, 2015, 31 (1), pp 292–298 doi: 10.1021/la504057z
Modelling the Bioelectronic Interface in Engineered Tethered Membranes: From Biosensing to Electroporation
William Hoiles ; Vikram Krishnamurthy ; Bruce Cornell
IEEE Transactions on Biomedical Circuits and Systems ( Volume: 9, Issue: 3, June 2015 ) 321 - 333 doi: 10.1109/TBCAS.2014.2357420
The Effect of Bias Potential on Tethered Lipid Bilayers
Stephen Holt et al
2nd Asia Oceania Conference on Neutron Scattering 2015
Earlier Publications
General
Supported Membranes: Scientific and Practical Applications. E. Sackmann. Science 5 January 1996: 43-48. doi:10.1126/science.271.5245.43
Ion Channels
Comparative Study of the Bacterial Sodium Channel NaChBac Function using Patch Clamp and A.C. Impedance Spectroscopy in a Tethered Membrane. BruceA.Cornell, Gwenael Scolan, Andrew M. Powl, Sonia Carne, Bonnie Wallace. Biophysical Journal, 102,3,338a,2012 DOI:10.1016/j.bpj.2011.11.1852
The protective effect of osmoprotectiveTMAO on bacterial mechanosensitive channels of small conductive MscS/MscK under high hydorstatic pressure. Evgeny Petrov, Paul Rohde, Bruce Cornell, and Boris Martinac. Channels, 6:4, 1-10, 2012 DOI: 10.4161/chan.20833
Ion Channel Proteins that Spontaneously Insert into Lipid Bilayer Membranes: An Impedance Spectroscopy Study Employing Tethered Membranes.
Bruce A. Cornell, Heba Alkhamici, Louise Brown, Sonia Carne, Sophia C. Goodchild, Russell Richards, and Stella M. Valenzuela. Biophysical Journal, 102, 682a-683a, 2012. DOI: 10.1016/j.bpj.2011.11.3710
A High-Throughput Technique for Screening Novel Antibacterial Agents Targeting Bacterial Mechanosensitive Channels.
Bruce A. Cornell, Andrew R. Battle, Sonia Carne, and Boris Martinac. Biophysical Journal, 102,122a, DOI: 10.1016/j.bpj.2011.11.683
Regulation of the Membrane Insertion and Conductance Activity of the Metamorphic Chloride Intracellular Channel Protein CLIC 1 by Cholesterol. Valenzuela, Stella M; Alkhamici, Heba; Brown, Louise J,; et al. PLOS ONE Volume 8 Issue 2 Article Number e56948 Feb 14,2013
Bacterial Mechanosensitive Channels: Models for Studying Mechanosensitive Transduction. Martinac, Boris; Nomura, Takeshi; Chi Gamma; et al. Antioxidants and Redox Signalling Volume: 20 Issue: 6 Pages: 952-969 Feb 20, 2014
Membranes
Making lipid membranes even tougher. Jognandan Prashar, Phillip Sharp, Mathew Scarffe, and Bruce Cornell. Journal of Materials Research, 22, 2189-2194, 2007. DOI: 10.1557/jmr.2007.0288
Tethered Bilayer Membranes Containing Ionic Reservoirs: Selectivity and Conductance. Gowri Krishna, Jurgen Schulte, Bruce A. Cornell, Ron J. Pace, and Peter D. Osman. Langmuir, 19, 2294–2305, 2003. DOI: 10.1021/la026238d
Tethered Bilayer Membranes Containing Ionic Reservoirs: The Interfacial Capacitance. Gowri Krishna, Jurgen Schulte, Bruce A. Cornell, Ron Pace, Lech Wieczorek, and Peter D. Osman. Langmuir, 17, 4858–4866, 2001. DOI: 10.1021/la001480a
Tethered-bilayer lipid membranes as a support for membrane-active peptides. B. A. Cornell, G. Krishna, P. D. Osman, R. D. Pace and L. Wieczorek. Biochemical Society Transactions, 29, 613–617, 2001. DOI: 10.1042/bst0290613
Tethered Lipid Bilayer Membranes: Formation and Ionic Reservoir Characterization. Burkhard Raguse, Vijoleta Braach-Maksvytis, Bruce A. Cornell, Lionel G. King, Peter D. J. Osman, Ron J. Pace, and Lech Wieczorek. Langmuir, 1998, 14, 648–659 1998. DOI: 10.1021/la9711239
A study of Functional Ion Transport Using Tethered Membranes. Cornell, Bruce A; Battle Andrew; Brown, Louise; et al. Biophysical Journal Volume: 100 Issue:3 Supplement 1 Page 338 Feb 2011
Biomimetic Membrane System Composed of a Lipid Bilayer Supported by an Interpenetrating Hydrogel for Usage as Replacement Membranes in Diffusion Chambers. Martin, Donald K; Alcarez, Jaen-Pierre; Stidder, Barry; et al. Abstracts of Papers of the American Chemical Society Volume: 245 Meeting Abstract 10-PHYS April 2013
An engineered membrane to measure electroporation: Effect of tethers and bioelectronic interface
William Hoiles, Vikram Krishnamurthy, Charles G. Cranfield, Bruce Cornell
Biophysical Journal Volume 107, Issue 6, 16 September 2014, Pages 1339–1351 dx.doi.org/10.1016/j.bpj.2014.07.056
Biosensor
A biosensor that uses ion-channel switches. Cornell BA, BraachMaksvytis VLB, King LG, et al. NATURE Volume: 387 Issue: 6633 Pages: 580-583 Published: JUN 5 1997
The ion channel switch biosensor. Woodhouse G, King L, Wieczorek L, et al. JOURNAL OF MOLECULAR RECOGNITION Volume: 12 Issue: 5 Pages: 328-334 Published: SEP-OCT 1999
Kinetics of the competitive response of receptors immobilised to ion-channels which have been incorporated into a tethered bilayer. Woodhouse GE, King LG, Wieczorek L, et al. FARADAY DISCUSSIONS Volume: 111 Issue: 111 Pages: 247-258 Published: 1998
Gramicidin ion channel-based biosensors: Construction, Stochastic dynamical models, and statistical detection algorithms. Krishnamurthy V, Luk KY, Cornell B, et al. IEEE SENSORS JOURNAL Volume: 7 Issue: 9-10 Pages: 1281-1288 Published: SEP-OCT 2007
Rapid detection of influenza A virus in clinical samples using an ion channel switch biosensor. Oh SY, Cornell B, Smith D, et al. BIOSENSORS & BIOELECTRONICS Volume: 23 Issue: 7 Pages: 1161-1165 Published: FEB 28 2008
Reconfigurable Ion-Channel based Biosensor: Input Excitation Design and Analyte Classification. Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce Proceedings of the 48th IEEE Conference on Decision and Control (CDC) / 28th Chinese Control Conference (CCC) Location: Shanghai, PEOPLES R CHINA Date: DEC 15-18, 2009
Mathematical modeling of a tethered bilayer sensor containing gramicidin A ion channels. Monfared, Sahar M; Krishnamurthy, Vikram; Cornell, Bruce Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Volume: 2009 Pages: 1262-5 2009
tochastic modeling and signal processing of nano-scale protein-based biosensors Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce. 7th IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS 2009).2009 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS (GENSIPS 2009) Pages: 154-159 2009
hemical Kinetics and Mass Transport in an Ion Channel Based Biosensor. Monfared, Sahar M.; Krishnamurthy, Vikram; Cornell, Bruce C. 49th IEEE Conference on Decision and Control (CDC) Location: Atlanta, GA, DEC 15-17, 2010. 49TH IEEE CONFERENCE ON DECISION AND CONTROL (CDC) Book Series: IEEE Conference on Decision and Control Pages: 4685-4690 2010
I
on Channel Biosensors Part I Construction Operation and Clinical Studies. Krishnamurthy V, Monfared SM, Cornell B. IEEE Transactions on Nanotechnology May 2010 Volume 9 No 3: Pages: 303-313 MAY 2010
Ion Channel Biosensors Part II Dynamic Modelling, Analysis and Statistical Signal Processing. Krishnamurthy V, Monfared SM, Cornell B. Transactions on Nanotechnology May 2010 Volume 9 No 3: Pages: 313-322 MAY 2010
Engineering aspects of biological ion channels-from biosensors to computational models for permeation . Krishnamurthy, Vikram; Cornell, Bruce PROTOPLASMA Volume: 249 Supplement: 1 Pages: S3-S9 Published: FEB 2012
A molecular machine biosensor: Construction, predictive models and experimental studies Moradi-Monfared, Sahar; Krishnamurthy, Vikram; Cornell, Bruce
BIOSENSORS & BIOELECTRONICS Volume: 34 Issue: 1 Pages: 261-266 Published: APR 15 2012
Multiple Surface-Based Biosensors for Enhanced Molecular Detection in Fluid Flow Systems Abolfath-Beygi, Maryam; Krishnamurthy, Vikram; Cornell, Bruce IEEE SENSORS JOURNAL Volume: 13 Issue: 4 Pages: 1265-1273 Published: APR 2013
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Small peptides and membrane pore forming biomaterials
A tethered bilayer sensor containing alamethicin channels and its detection of amiloride based inhibitors. Yin P, Burns CJ, Osman PDJ, et al. BIOSENSORS & BIOELECTRONICS Volume: 18 Issue: 4 Pages: 389-397 APR 2003
Tethered-bilayer lipid membranes as a support for membrane-active peptides. Cornell BA, Krishna G, Osman PD, et al. BIOCHEMICAL SOCIETY TRANSACTIONS Volume: 29 Pages: 613-617 Part: Part 4 AUG 2001
A High-Throughput Technique for Screening Novel Antibacterial Agents Targeting Bacterial Mechanosensitive Channels. Cornell, Bruce A.; Battle, Andrew R.; Carne, Sonia; et al. 56th Annual Meeting of the Biophysical-Society Location: San Diego, CA Date: FEB 25-29, 2012 BIOPHYSICAL JOURNAL Volume: 102 Issue: 3 Supplement: 1 Pages: 122A-122A JAN 31 2012 doi:10.1016/j.bpj.2011.11.683
Characterization of Antimicrobial Peptide Insertion in Tethered Bilayer Lipid Membranes by Pulse Amperometry and Linear Sweep Voltammetry Methods Cranfield, Charles G.; Cornell, Bruce; Grage, Stephan L.; et al. Conference: 57th Annual Meeting of the Biophysical-Society Location: Philadelphia, PA Date: FEB 02-06, 2013 BIOPHYSICAL JOURNAL Volume: 104 Issue: 2 Supplement: 1 Pages: 600A-600A JAN 29 2013 doi:10.1016/j.bpj.2012.11.3330
Transient Potential Gradients and Impedance Measures of Tethered Bilayer Lipid Membranes: Pore-Forming Peptide Insertion and the Effect of Electroporation. Cranfield, Charles G.; Cornell, Bruce A.; Grage, Stephan L.; et al. BIOPHYSICAL JOURNAL Volume: 106 Issue: 1 Pages: 182-189 Published: JAN 7 2014 doi:10.1016/j.bpj.2013.11.1121
Screening the Insertion of Families of Bioactive Microbial Metabolites into Tethered Bilayer Lipid Membranes (TBLMS). Cranfield, Charles G.; Carne, Sonia; Alkhamici, Heba; et al. 58th Annual Meeting of the Biophysical-Society Location: San Francisco, CA Date: FEB 15-19, 2014 BIOPHYSICAL JOURNAL Volume: 106 Issue: 2 Supplement: 1 Pages: 294A-294A JAN 28 2014 doi:10.1016/j.bpj.2013.11.1714.